The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

doi:10.1016/j.immuni.2013.08.006

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Article

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

Immunity - 22 Aug 2013

Chen Zuojia, Barbi Joseph, Bu Shurui, Yang Huang-Yu, Li Zhiyuan, Gao Yayi, Jinasena Dilini, Fu Juan, Lin Fang, Chen Chen, Zhang Jing, Yu Ning, Li Xiangpei, Shan Zhao, Nie Jia, Gao Zhimei, Tian Hong, Li Yangyang, Yao Zhengju, Zheng Ying, Park Benjamin V, Pan Ziyi, Zhang Jing, Dang Eric, Li Zhiguang, Wang Honglin, Luo Weibo, Li Liwu, Semenza Gregg L, Zheng Song-Guo, Loser Karin, Tsun Andy, Greene Mark I, Pardoll Drew M, Pan Fan, Li Bin

Abstract excerpt

Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self-reactive T cells. The key Treg cell transcription factor Foxp3 is downregulated during inflammation to allow for the acquisition of effector T cell-like functions. Here, we demonstrate that stress sig...

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PMID: 23973223
DOI: 10.1016/j.immuni.2013.08.006
PMCID: PMC3817295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23973223-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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