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Article

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018

Kwon Ho-Keun, Chen Hui-Min, Mathis Diane, Benoist Christophe

Abstract excerpt

FoxP3+ regulatory T cells (Tregs) are a central element of immunological tolerance. FoxP3 is the key determining transcription factor of the Treg lineage, interacting with numerous cofactors and transcriptional targets to determine the many facets of Treg function. Its absence leads to devastating lymphoproliferation and autoimmunity in scurfy mutant mice and immunodysregulation polyendocrinopathy enteropathy...

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Identifiers

PMID: 29269391
DOI: 10.1073/pnas.1718599115
PMCID: PMC5777076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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