Article

Foxp3 in the Immune System

2024-12-11

Abstract excerpt

Regulatory T cells (Tregs) play a central role in immune regulation and tolerance. The transcription factor FOXP3 is a master regulator of Tregs in both humans and mice. Mutations in FOXP3 lead to the development of IPEX syndrome in humans and the scurfy phenotype in mice, both of which are characterized by fatal systemic autoimmunity. Additionally, Treg dysfunction and FOXP3 expression instability have been impli...

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Literature Corpus work: e74b43c5-2fb9-5d96-9383-4974c511b98d
DOI: 10.20944/preprints202412.0957.v1

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