Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3

Abstract excerpt

<h4>SUMMARY</h4> FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T cells (Tconvs). Mechanisms governing these distinct expression patterns remain unknown. Here, we performed CRISPR screens tiling the FOXP3 locus and targeting TFs in human Tr...

Topics

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• CRISPR-Cas Systems
• Dependovirus
• Forkhead Transcription Factors
• Gene Knock-In Techniques
• Immunosuppression Therapy
• Interleukin-2
• Lymphocyte Subsets
• T-Lymphocytes, Regulatory

Identifiers and source

Literature Corpus work

89562368-52c8-5ff6-af57-59aa1d0ac1a9

DOI

10.1101/2024.08.30.610436