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Pentoxifylline, a Non-Antibiotic Drug, Promotes Adaptation of Clinical Isolates of <i>Staphylococcus aureus</i> via Modulating c-di-AMP Signaling

2025-09-09

Abstract excerpt

This study investigated how Staphylococcus aureus adapts under pentoxifylline (PTX) therapy through analyzing three phylogenetically related isolates (L1, L2, L3) from a bacteremia patient. Whole genome sequencing revealed L1 contained a 2400-bp insertion disrupting nupC , while L3 harbored mutations in the anti-Shine-Dalgarno sequences of 16S rRNA. Each isolate evolved distinct mechanisms to reduce c-di-AMP lev...

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Literature Corpus work
8e4ce578-dc0f-5d39-8a52-d5c139e147b0
DOI
10.1101/2025.09.09.675175
Open publication

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Pentoxifylline, a Non-Antibiotic Drug, Promotes Adaptation of Clinical Isolates of <i>Staphylococcus aureus</i> via Modulating c-di-AMP SignalingDOI 10.1101/2025.09.09.675175
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