Article

Loss of GdpP function in <i>Staphylococcus aureus</i> leads to β-lactam tolerance and enhanced evolution of β-lactam resistance

2021-07-02

Abstract excerpt

<h4>Synopsis</h4> <h4>Background</h4> We previously reported the presence of mutations in gdpP among Staphylococcus aureus strains that were obtained by serial passaging in β-lactam drugs. gdpP codes for a phosphodiesterase that cleaves cyclic-di-AMP (CDA), a newly discovered second messenger. <h4>Objectives</h4> We sought to identify the role of gdpP in β-lactam resistance of S. aureus . <h4>Methods</h4...

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Literature Corpus work: 8745055e-ddbc-540a-8afa-1eb944f4eac6
DOI: 10.1101/2021.07.02.449101

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