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C-di-AMP levels modulate <i>Staphylococcus aureus</i> cell wall thickness as well as virulence and contribute to antibiotic resistance and tolerance

2023-04-20

Abstract excerpt

Beta-lactam antibiotics are widely used to treat infections caused by the important human pathogen Staphylococcus aureus . Resistance to beta-lactams, as found in methicillin-resistant S. aureus (MRSA), renders effective treatment difficult. The second messenger cyclic di-3′,5′- adenosine monophosphate (c-di-AMP) promotes beta-lactam resistance in clinical S. aureus isolates. C-di-AMP plays a crucial role in th...

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Literature Corpus work
b90b182f-1e8f-5512-a587-30dd78041da4
DOI
10.1101/2023.04.18.537236
Open publication

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C-di-AMP levels modulate <i>Staphylococcus aureus</i> cell wall thickness as well as virulence and contribute to antibiotic resistance and toleranceDOI 10.1101/2023.04.18.537236
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