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Article

Statin-induced lipid carrier stress reveals a conserved vulnerability in β-lactam-resistant Gram-positive bacteria.

Nature communications - 20 Jul 2026

Torrens Gabriel, Bisset Sean W, López-Bravo Maria, Johansson Anders F, Lopez Daniel, Cava Felipe

Abstract excerpt

Methicillin-resistant Staphylococcus aureus resists β-lactam antibiotics through the allosteric transpeptidase penicillin-binding protein 2a, which operates within staphyloxanthin-rich membrane microdomains. Statins restore susceptibility by disrupting these microdomains and impairing penicillin-binding protein 2a oligomerization, but the mechanisms enabling resistance to this resensitization remain unclear. Here...

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Gram-Positive Bacteria
Membrane Microdomains
Mevalonic Acid
Oxacillin
Penicillin-Binding Proteins

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Polyisoprenyl Phosphates

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PMID: 42477355
DOI: 10.1038/s41467-026-75729-8
PMCID: PMC13385884

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