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Loss of GdpP function in <i>Staphylococcus aureus</i> confers β-lactam-specific antibiotic tolerance and promotes invasive infection

2026-08-24

Abstract excerpt

The emergence of antibiotic tolerance in Staphylococcus aureus reduces antibiotic efficacy by allowing bacterial survival despite prolonged antibiotic exposure, the molecular basis of which remains poorly understood. Moreover, the phenotypic indistinguishability of tolerant isolates in antimicrobial susceptibility testing impedes effective diagnosis and therapy. Increased concentration of the second-messenger, cy...

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Literature Corpus work
65101032-cae6-5297-83e9-a53010e7539a
DOI
10.64898/2026.07.27.740951
Open publication

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Loss of GdpP function in <i>Staphylococcus aureus</i> confers β-lactam-specific antibiotic tolerance and promotes invasive infectionDOI 10.64898/2026.07.27.740951
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