Article

Coordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B <i>Streptococcus</i>

2024-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Streptococcus agalactiae is among the few pathogens that have not developed resistance to ß-lactam antibiotics despite decades of clinical use. The molecular basis of this long-lasting susceptibility has not been investigated, and it is not known whether specific mechanisms constrain the emergence of resistance. In this study, we report the conserved role of the signaling nucleotide cyclic-di-AM...

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Literature Corpus work: c82cf81c-eb10-5b02-b26e-2e162a5629a1
DOI: 10.1101/2024.03.27.586946

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