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C-di-AMP levels modulate Staphylococcus aureus cell wall thickness, response to oxidative stress, and antibiotic resistance and tolerance

10 Nov 2023

Abstract excerpt

ABSTRACT Beta-lactam antibiotics are widely used to treat infections caused by the important human pathogen Staphylococcus aureus . Resistance to beta-lactams, as found in methicillin-resistant S. aureus , renders effective treatment difficult. The second messenger cyclic di-3′,5′-adenosine monophosphate (c-di-AMP) promotes beta-lactam resistance in clinical S. aureus isolates. C-di-AMP plays a crucial role in...

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PMID: 37948390
DOI: 10.1128/spectrum.02788-23

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