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Article

Rapid and Consistent Evolution of Colistin Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa during Morbidostat Culture.

Antimicrobial agents and chemotherapy - 1 Sept 2017

Dößelmann Bianca, Willmann Matthias, Steglich Matthias, Bunk Boyke, Nübel Ulrich, Peter Silke, Neher Richard A

Abstract excerpt

Colistin is a last-resort antibiotic commonly used against multidrug-resistant strains of Pseudomonas aeruginosa To investigate the potential for in situ evolution of resistance against colistin and to map the molecular targets of colistin resistance, we exposed two P. aeruginosa isolates to colistin using a continuous-culture device known as a morbidostat. As a result, colistin resistance reproducibly increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28630206
DOI: 10.1128/AAC.00043-17
PMCID: PMC5571341

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