Article

Single cell long read whole genome sequencing reveals somatic transposon activity in human brain

2024-11-11

Abstract excerpt

The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impact. In this work we discover novel dynamics in three brains utilizing single cell long-read sequencing. This provides key insights into the dynamic of the genomes of individual cells and further highlights brain speci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e410083-65c5-5f5f-9fca-e71d9dfe4782
DOI: 10.1101/2024.11.11.24317113

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell long read whole genome sequencing reveals somatic transposon activity in human brainDOI 10.1101/2024.11.11.24317113Read

Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brainSemantic proximity Read

Active Human Transposable Elements: Long-Read Sequencing Technologies, Computational Analysis, and Implications for Human DiseaseSemantic proximity Read

Cell lineage analysis in human brain using endogenous retroelements.Semantic proximity Read

Somatic mutation in single human neurons tracks developmental and transcriptional history.Semantic proximity Read

Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.Semantic proximity Read

Disease insights from brain somatic mosaicism.Semantic proximity Read

Genomic mosaicism in the developing and adult brainSemantic proximity Read

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and gliaSemantic proximity Read

A high throughput screen for active human transposable elementsSemantic proximity Read

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).Semantic proximity Read

A personalized multi-platform assessment of somatic mosaicism in the human frontal cortexSemantic proximity Read

A high throughput screen for active human transposable elements.Semantic proximity Read