Article
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain.
Cell - 26 Oct 2012
Evrony Gilad D, Cai Xuyu, Lee Eunjung, Hills L Benjamin, Elhosary Princess C, Lehmann Hillel S, Parker J J, Atabay Kutay D, Gilmore Edward C, Poduri Annapurna, Park Peter J, Walsh Christopher A
Abstract excerpt
A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurological disease. To address this question, we developed a method to amplify genomes of single neurons from human brains. Because recent reports suggest frequent LINE-1 (L1) retrotransposition in human brains, we...
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