Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).

Science (New York, N.Y.) - 14 Apr 2017

Chen Chongyi, Xing Dong, Tan Longzhi, Li Heng, Zhou Guangyu, Huang Lei, Xie X Sunney

Abstract excerpt

Single-cell genomics is important for biology and medicine. However, current whole-genome amplification (WGA) methods are limited by low accuracy of copy-number variation (CNV) detection and low amplification fidelity. Here we report an improved single-cell WGA method, Linear Amplification via Transposon Insertion (LIANTI), which outperforms existing methods, enabling micro-CNV detection with kilobase resolution....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosine
Share to Deamination
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Transposable Elements

Share to Mutagenesis, Insertional

Share to Replication Origin

Share to Single-Cell Analysis

Share to Thymine

Source

Open in PubMed Open full text

Identifiers

PMID: 28408603
DOI: 10.1126/science.aak9787
PMCID: PMC5538131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).PMID 28408603Read ↗

Accurate SNV detection in single cells by transposon-based whole-genome amplification of complementary strands.Semantic proximity Read ↗

SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform.Semantic proximity Read ↗

Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.Semantic proximity Read ↗

Low frequency somatic copy number alterations in normal human lymphocytes revealed by large scale single-cell whole genome profilingSemantic proximity Read ↗

Down the Rabbit Hole of Single-Cell Genome Analysis.Semantic proximity Read ↗

Comparison of single-cell whole-genome amplification strategiesSemantic proximity Read ↗

Single-Cell Whole-Genome Amplification and Sequencing: Methodology and ApplicationsSemantic proximity Read ↗

A comprehensive view of somatic mosaicism by single-cell DNA analysisSemantic proximity Read ↗

Future medical applications of single-cell sequencing in cancerSemantic proximity Read ↗

Analyzing somatic mutations by single-cell whole-genome sequencing.Semantic proximity Read ↗

Sensitive multimodal profiling of native DNA by transposase-mediated single-molecule sequencingSemantic proximity Read ↗

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.