Article

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

2019-06-06

Abstract excerpt

Active retrotransposons in the human genome (L1, Alu and SVA elements) can create genomic mobile element insertions (MEIs) in both germline and somatic tissue 1 . Specific somatic MEIs have been detected at high levels in human cancers 2 , and at lower to medium levels in human brains 3 . Dysregulation of somatic retrotransposition in the human brain has been hypothesized to contribute to neuropsychiatric dise...

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Literature Corpus work: c8c27deb-2020-5a12-a093-d1ed7aa44ca6
DOI: 10.1101/660779

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