Article

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

2018-08-14

Abstract excerpt

Patterns of gene expression are primarily determined by proteins that locally enhance or repress transcription. While many transcription factors target a restricted number of genes, others appear to modulate transcription levels globally. An example is MeCP2, an abundant methylated-DNA binding protein that is mutated in the neurological disorder Rett Syndrome. Despite much research, the molecular mechanism by whic...

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Literature Corpus work: 8e37034f-23f9-594c-b8d4-5d086f5d7abd
DOI: 10.1101/391904

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