Article

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

2019-03-23

Abstract excerpt

<h4>Summary</h4> Loss of function mutations in Methyl-CpG-binding Protein 2 (MeCP2) cause the severe neurological disorder Rett Syndrome. MeCP2 is a highly abundant nuclear protein particularly enriched in neurons. Although biochemical and genomic analyses of MeCP2-DNA interaction and genomic distribution demonstrate that MeCP2 binding on chromatin is dependent on DNA modification state, the dynamic behavior of i...

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Literature Corpus work: 1e7403e1-7ee5-5947-a108-eab8515705b3
DOI: 10.1101/586867

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