Article
MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes.
Molecular cell - 16 Jan 2020
Boxer Lisa D, Renthal William, Greben Alexander W, Whitwam Tess, Silberfeld Andrew, Stroud Hume, Li Emmy, Yang Marty G, Kinde Benyam, Griffith Eric C, Bonev Boyan, Greenberg Michael E
Abstract excerpt
Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome and MeCP2 mutations are associated with widespread small-magnitude changes in neuronal gene expression. We demonstrate here that MeCP2 represses nascent RNA transcription of...
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