Article
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.
Neuron - 19 Jun 2024
Liu Yi, Flamier Anthony, Bell George W, Diao Annette Jun, Whitfield Troy W, Wang Hao-Che, Wu Yizhe, Schulte Fabian, Friesen Max, Guo Ruisi, Mitalipova Maisam, Liu X Shawn, Vos Seychelle M, Young Richard A, Jaenisch Rudolf
Abstract excerpt
Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in normal and disease states is unresolved; it has been reported to be an activator and a repressor. We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type (WT) and mutant MECP2 molecules....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.