MeCP2 MBD-ID module: a unified DNA/RNA binding interface disrupted in Rett syndrome.

Abstract excerpt

Rett syndrome neurodevelopmental disorder is caused by mutations in the epigenetic regulator MeCP2. While the MeCP2 methyl-CpG binding domain (MBD) is well-characterized, the function of the adjacent intervening domain (ID) remains largely understudied. The ID has been described as a distinct RNA-binding region, yet evidence also suggests RNA competitively displaces MeCP2 from DNA. Here, we address these...

Topics

• Methyl-CpG-Binding Protein 2
• Rett Syndrome
• Humans
• DNA
• RNA
• Mutation
• Protein Binding