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Article

MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites.

Molecular and cellular biology - 1 Oct 2010

Ghosh Rajarshi P, Horowitz-Scherer Rachel A, Nikitina Tatiana, Shlyakhtenko Luda S, Woodcock Christopher L

Abstract excerpt

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome (RTT). In the present work, employing a wide range of experimental approaches, we shed new light on the many levels of MeCP2 interaction with DNA and chromatin. We show that strong methylation-independent as well as methylation-dependent...

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Identifiers

PMID: 20679481
DOI: 10.1128/MCB.00379-10
PMCID: PMC2950531

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MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites.PMID 20679481Read ↗

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