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Article

Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.

Nature structural & molecular biology - 1 Nov 2024

Chua Gabriella N L, Watters John W, Olinares Paul Dominic B, Begum Masuda, Vostal Lauren E, Luo Joshua A, Chait Brian T, Liu Shixin

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), a severe neurological disorder that primarily affects young females. The canonical view of MeCP2 as a DNA methylation-dependent transcriptional repressor has proven insufficient to describe its dynamic interaction with chromatin and multifaceted roles in genome organization and gene...

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Identifiers

PMID: 39164525
DOI: 10.1038/s41594-024-01373-9
PMCID: PMC11564119

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Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.PMID 39164525Read ↗

Differential dynamics specify MeCP2 function at methylated DNA and nucleosomesSemantic proximity Read ↗

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