Article

MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes

2023-02-26

Abstract excerpt

<h4>Summary</h4> A unique signature of neuronal transcriptomes is the high expression of the longest genes in the genome (e.g. >100 kilobases). These genes encode proteins with essential functions in neuronal physiology, and disruption of long gene expression has been implicated in neurological disorders. DNA topoisomerases resolve topological constraints that arise on DNA and facilitate the expression of long ge...

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Literature Corpus work: 463d50ef-60d2-56b8-8dce-f879b8ba326d
DOI: 10.1101/2023.02.24.529960

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