Article

MECP2 MBD-ID Module: A Unified DNA/RNA Binding Interface Disrupted in Rett Syndrome

2026-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome neurodevelopmental disorder is caused by mutations in the gene encoding the epigenetic regulator MECP2. While the MECP2 methyl-CpG binding domain (MBD) is well-characterized, the function of the adjacent intervening domain (ID) remains largely understudied. The ID has been described as a distinct RNA-binding region, yet evidence also suggests RNA competitively displaces MECP2 from...

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Literature Corpus work: 1dd1fcda-1ce9-5225-a478-3782f2d77eed
DOI: 10.64898/2026.02.15.706016

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