Article

Differential dynamics specify MeCP2 function at methylated DNA and nucleosomes

2023-06-05

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), a leading cause of monogenic intellectual disabilities in females. Despite its significant biomedical relevance, the mechanism by which MeCP2 navigates the chromatin epigenetic landscape to regulate chromatin structure and gene expression remains unclear. Here, we used correlative single-molecu...

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Literature Corpus work: fa306254-df44-5649-b729-1859a7bfa8ec
DOI: 10.1101/2023.06.02.543478

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