Article

Pleiotropic heritability quantifies the shared genetic variance of common diseases

2025-06-11

Abstract excerpt

Common diseases are highly pleiotropic, but the overall contribution of pleiotropy to a target disease’s architecture is unknown, as most studies focus on genetic correlations with each auxiliary disease in turn. Here we propose a new method, pleiotropic heritability with bias correction (PHBC), to estimate pleiotropic heritability ( h 2 pleio ), defined as the liability-scale genetic variance of a target disease...

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Literature Corpus work: 8dfafb02-ddf1-5c4d-b4c3-65d7a42a8665
DOI: 10.1101/2025.06.10.25329261

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