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Article

A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.

BMC medicine - 13 Dec 2021

Lu Haojie, Qiao Jiahao, Shao Zhonghe, Wang Ting, Huang Shuiping, Zeng Ping

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWASs) have revealed the polygenic nature of psychiatric disorders and discovered a few of single-nucleotide polymorphisms (SNPs) associated with multiple psychiatric disorders. However, the extent and pattern of pleiotropy among distinct psychiatric disorders remain not completely clear. METHODS: We analyzed 14 psychiatric disorders using summary statistics...

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Identifiers

PMID: 34895209
DOI: 10.1186/s12916-021-02186-z
PMCID: PMC8667366

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