Dissecting the high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability.

doi:10.1016/j.ajhg.2023.08.006

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Article

Dissecting the high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability.

American journal of human genetics - 7 Sept 2023

Miao Lin, Jiang Lin, Tang Bin, Sham Pak Chung, Li Miaoxin

Abstract excerpt

Despite extensive research on global heritability estimation for complex traits, few methods accurately dissect local heritability. A precise local heritability estimate is crucial for high-resolution mapping in genetics. Here, we report the effective heritability estimator (EHE) that can use p values from genome-wide association studies (GWASs) for local heritability estimation by directly converting marginal...

Topics

Genome-Wide Association Study
Genomics
Multifactorial Inheritance
Phenotype
Polymorphism, Single Nucleotide

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Identifiers

PMID: 37633278
DOI: 10.1016/j.ajhg.2023.08.006
PMCID: PMC10502872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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