Article

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks

2025-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Large-scale genetic association studies have identified thousands of trait-associated risk loci, establishing the polygenic basis for common complex traits and diseases. Although prior studies suggest that many trait-associated loci are pleiotropic, the extent to which this pleiotropy reflects shared causal variants or confounding by linkage disequilibrium remains poorly characterized. To define...

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Literature Corpus work: c3dabe12-79ee-5307-90d9-21c90dcae7cc
DOI: 10.1101/2025.04.18.25326074

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