Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimating and testing pleiotropy of single genetic variant for two quantitative traits.

Genetic epidemiology - 1 Sept 2014

Zhang Qunyuan, Feitosa Mary, Borecki Ingrid B

Abstract excerpt

Along with the accumulated data of genetic variants and biomedical phenotypes in the genome era, statistical identification of pleiotropy is of growing interest for dissecting and understanding genetic correlations between complex traits. We proposed a novel method for estimating and testing pleiotropic effect of a genetic variant on two quantitative traits. Based on a covariance decomposition and estimation, our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Pleiotropy
Share to Genetic Variation
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 25044106
DOI: 10.1002/gepi.21837
PMCID: PMC4169079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimating and testing pleiotropy of single genetic variant for two quantitative traits.PMID 25044106Read ↗

Dissecting pleiotropy to gain mechanistic insights into human disease.Semantic proximity Read ↗

Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants.Semantic proximity Read ↗

The Combined Analysis of Pleiotropy and Epistasis (CAPE).Semantic proximity Read ↗

Pleiotropy in complex traits: challenges and strategies.Semantic proximity Read ↗

Pleiotropic heritability quantifies the shared genetic variance of common diseasesSemantic proximity Read ↗

The detection and characterization of pleiotropy: discovery, progress, and promise.Semantic proximity Read ↗

Shared components of heritability across genetically correlated traitsSemantic proximity Read ↗

Shared components of heritability across genetically correlated traits.Semantic proximity Read ↗

A plethora of pleiotropy across complex traits.Semantic proximity Read ↗

Joint Modeling of Effect Sizes for Two Correlated Traits: Characterizing Trait Properties to Enhance Polygenic Risk PredictionSemantic proximity Read ↗

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read ↗

The ubiquity of pleiotropy in human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.