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Article

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases.

Nature genetics - 1 Jun 2026

Zhao Yujie, Strober Benjamin, Hou Kangcheng, Kerner Gaspard, Danesh John, Gazal Steven, Cheng Wei, Inouye Michael, Price Alkes L, Jiang Xilin

Abstract excerpt

The overall contribution of pleiotropy to disease architectures is unknown, as most studies estimate genetic correlations with each auxiliary disease in turn. Here we propose a method-pleiotropic shared heritability with bias correction (PHBC)-to estimate the liability-scale genetic variance of a target disease that is shared with a specific set of auxiliary diseases ( h 2 pleio ). PHBC estimates h 2 pleio from a...

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Identifiers

PMID: 42265310
DOI: 10.1038/s41588-026-02607-w
PMCID: PMC13256260

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