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Article

A cross-disease, pleiotropy-driven approach for therapeutic target prioritization and evaluation.

Cell reports methods - 22 Apr 2024

Bao Chaohui, Tan Tingting, Wang Shan, Gao Chenxu, Lu Chang, Yang Siyue, Diao Yizhu, Jiang Lulu, Jing Duohui, Chen Liye, Lv Haitao, Fang Hai

Abstract excerpt

Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts pleiotropic effects across multiple diseases. However, the challenge "W-H-W" (namely, whether, how, and in which specific diseases pleiotropy can inform clinical therapeutics) calls for effective and integrative approaches and tools. We here introduce a...

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Identifiers

PMID: 38631345
DOI: 10.1016/j.crmeth.2024.100757
PMCID: PMC11046034

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