Dissecting pleiotropy to gain mechanistic insights into human disease.

Abstract excerpt

Pleiotropy is the phenomenon by which a genetic variant affects multiple independent traits. Human genetics studies have identified pervasive pleiotropy throughout the genome and multitrait genome-wide association studies are growing in scale, such that dissecting pleiotropy is an increasingly important step in linking disease-associated variants to specific mechanisms. Dissecting pleiotropy entails using one of...

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