Article

Joint Modeling of Effect Sizes for Two Correlated Traits: Characterizing Trait Properties to Enhance Polygenic Risk Prediction

2025-05-01

Abstract excerpt

Recent years have witnessed a surge in the development of innovative polygenic score (PGS) methods, driving their extensive application in disease prevention, monitoring, and treatment. However, the accuracy of genetic risk prediction remains moderate for most traits. Currently, most PGSs were built based on the summary statistics from the target trait, while many traits exhibit varied degrees of shared genetic ar...

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Literature Corpus work: 55095ece-20a4-5d78-95eb-3bfbc3a85c76
DOI: 10.1101/2025.04.28.650892

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