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Article

Joint modeling of effect sizes for two correlated traits: Characterizing trait properties to enhance polygenic risk prediction.

PLoS genetics - 1 Jan 2026

Zhang Chi, Zhou Geyu, Chen Tianqi, Zhao Hongyu

Abstract excerpt

Recent years have witnessed a surge in the development of innovative polygenic score (PGS) methods, driving their extensive application in disease prevention, monitoring, and treatment. However, the accuracy of genetic risk prediction remains moderate for most traits. Currently, most PGSs were built based on the summary statistics from the target trait, while many traits exhibit varied degrees of shared genetic...

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Identifiers

PMID: 41587179
DOI: 10.1371/journal.pgen.1012026
PMCID: PMC12858075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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