Article

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

2024-09-20

Abstract excerpt

Endosomal system dysfunction within neurons is a prominent early feature of Alzheimer’s disease (AD) pathology. Multiple AD risk factors are regulators of endocytosis and are known to cause hyper-activity of the early-endosome small GTPase rab5, resulting in neuronal endosomal pathway disruption and cholinergic neurodegeneration. Adaptor protein containing Pleckstrin homology domain, Phosphotyrosine binding domain...

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Literature Corpus work: 8da03130-4d4b-5e59-b1d6-eac1de967898
DOI: 10.1101/2024.09.19.613736

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Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationDOI 10.1101/2024.09.19.613736Read

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