Article

The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia

2023-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Adaptor protein complex 4 (AP-4) is a heterotetrameric complex that promotes protein export from the trans -Golgi network. Mutations in each of the AP-4 subunits cause a complicated form of Hereditary Spastic Paraplegia (HSP). Herein, we report that ApoER2, a receptor in the Reelin signaling pathway, is a cargo of the AP-4 complex. We identify the motif ISSF/Y within the ApoER2 cytosolic domain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6392f59b-8552-5035-b545-9a68a0eb1724
DOI: 10.1101/2023.12.21.572896

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic ParaplegiaDOI 10.1101/2023.12.21.572896Read

The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of ApoE4 in Alzheimer DiseaseSemantic proximity Read

AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi networkSemantic proximity Read

Heterogeneity of novel APOER2 isoforms specific to Alzheimer’s disease impact cellular and synaptic statesSemantic proximity Read

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationSemantic proximity Read

The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia.Semantic proximity Read

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndromeSemantic proximity Read

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein traffickingSemantic proximity Read

Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loadingSemantic proximity Read

ESCRT-0 regulates AMPA receptor currents and Ca <sup>2+</sup> - dependent signalingSemantic proximity Read

The membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment.Semantic proximity Read

The Epsilon Hinge‐Ear Region Regulates Membrane Localization of the AP‐4 ComplexSemantic proximity Read

REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity.Semantic proximity Read