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Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

2020-03-31

Abstract excerpt

<title>Abstract</title> <p>Background: Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer’s disease (AD). Recent evidence has suggested that packaging and secretion of APP and its amyloidogenic cleaved product (βAPP) into small extracellular vesicles (EVs) may facilitate uptake of these neurotoxic factors du...

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Literature Corpus work
a8a8802a-a30c-5dc9-8f2c-153b95c1395d
DOI
10.21203/rs.2.22338/v2
Open publication

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