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Article

Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.

The Journal of cell biology - 30 Mar 2015

West Ryan J H, Lu Yubing, Marie Bruno, Gao Fen-Biao, Sweeney Sean T

Abstract excerpt

Mutations in genes essential for protein homeostasis have been identified in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Why mature neurons should be particularly sensitive to such perturbations is unclear. We identified mutations in Rab8 in a genetic screen for enhancement of an FTD phenotype associated with ESCRT-III dysfunction. Examination of Rab8 mutants or motor neurons...

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Identifiers

PMID: 25800055
DOI: 10.1083/jcb.201404066
PMCID: PMC4384727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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