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Dysregulation of Rab5‐mediated endocytic pathways in Alzheimer's disease

3 Jan 2018

Abstract excerpt

Increasing evidence has pointed to that dysregulation of the endo-lysosomal system is an early cellular phenotype of pathogenesis for Alzheimer's disease (AD). Rab5, a small GTPase, plays a critical role in mediating these processes. Abnormal overactivation of Rab5 has been observed in post-mortem brain samples of Alzheimer's patients as well as brain samples of mouse models of AD. Recent genome-wide association...

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PMID: 29314494
DOI: 10.1111/tra.12547

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