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Article

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Cell reports - 11 Oct 2016

Woodruff Grace, Reyna Sol M, Dunlap Mariah, Van Der Kant Rik, Callender Julia A, Young Jessica E, Roberts Elizabeth A, Goldstein Lawrence S B

Abstract excerpt

We investigated early phenotypes caused by familial Alzheimer's disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci revealed that fAD mutant neurons had previously unreported defects in the recycling state of endocytosis and soma-to-axon transcytosis of APP and lipoproteins. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27732852
DOI: 10.1016/j.celrep.2016.09.034
PMCID: PMC5796664

Genes

APP

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