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Article

Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease

17 Apr 2020

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease progression is synapse loss. What causes synapse loss has been the focus of several researchers in the AD field. Synapses become dysfunctional before plaques and tangles...

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PMID: 32362813
DOI: 10.3389/fncel.2020.00072

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