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The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets

14 Jul 2025

Abstract excerpt

The Rab3 protein family is composed of a series of small GTP-binding proteins, including Rab3a, Rab3b, Rab3c, and Rab3d, termed Rab3s. They play crucial roles in health, including in brain function, such as through the regulation of synaptic transmission and neuronal activities. In the high-energy-demanding and high-traffic neurons, the Rab3s regulate essential cellular processes, including trafficking of...

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PMID: 40659647
DOI: 10.1038/s41514-025-00257-6

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