Article

L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation

2024-12-02

Abstract excerpt

Metabolic reprogramming is critical for immune cell adaptation upon activation to exert full functionality with amino acids being a key metabolic factor. While L-asparagine is a non- essential amino acid it turns out to be conditionally essential in malignant B cells due to defective asparagine synthetase making L-asparaginase a commonly used chemotherapeutic agent. Off-target enzymatic activity including glutamin...

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Literature Corpus work: 8d930088-f921-5cfc-a0ba-6ff2fd6dbbab
DOI: 10.1101/2024.11.27.625617

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