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Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase

5 Jun 2020

Abstract excerpt

BACKGROUND: Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparaginase; however, the mechanism underlying their inter-individual differences is still not fully understood. We have previously shown that L-asparaginase rewires the biosynthetic and bioenergetic...

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PMID: 32503472
DOI: 10.1186/s12885-020-07020-y

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