Article

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

2022-07-18

Abstract excerpt

Robust and effective T cell immune surveillance and cancer immunotherapy require properly allocating metabolic resources to sustain energetically costly processes, including growth and cytokine production. Amino acids are major cellular constituents that serve as protein building blocks, energy sources, and signaling molecules. Although T cells can synthesize all nonessential amino acids, including asparagine (Asn...

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Literature Corpus work: 7721d183-5dfc-54bd-82da-057db0cbd954
DOI: 10.1101/2022.07.18.500458

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