Article
Nonclinical Evaluation of Single-Mutant E. coli Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses.
International journal of molecular sciences - 30 May 2024
Ruiz-Lara Grace, Costa-Silva Tales A, Muso-Cachumba Jorge Javier, Cevallos Espinel Johanna, Fontes Marina Gabriel, Garcia-Maya Mitla, Rahman Khondaker Miraz, Rangel-Yagui Carlota de Oliveira, Monteiro Gisele
Abstract excerpt
Acute lymphoblastic leukaemia is currently treated with bacterial L-asparaginase; however, its side effects raise the need for the development of improved and efficient novel enzymes. Previously, we obtained low anti-asparaginase antibody production and high serum enzyme half-life in mice treated with the P40S/S206C mutant; however, its specific activity was significantly reduced. Thus, our aim was to test single...
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