Article

Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

2025-05-09

Abstract excerpt

<h4>ABSTRACT</h4> The efficiencies with which activated B lymphocytes proliferate and develop into antibody (Ab)-secreting plasma cells are critical determinants of adaptive humoral immunity and sustain certain autoimmune diseases. Specific pathways in intermediary metabolism, or their substrate supply, influence lymphocyte differentiation and function. We now show that although stringent restriction of glutamine...

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Literature Corpus work: 4f5fab5d-4a65-58c8-96e1-3283cdc0e674
DOI: 10.1101/2025.05.05.652119

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