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Article

A clinically attainable dose of L‐asparaginase targets glutamine addiction in lymphoid cell lines

2 Sept 2015

Abstract excerpt

L-asparaginase (L-ASNase) is an important branch of chemotherapy for acute lymphoblastic leukemia (ALL) and some types of non-Hodgkin's lymphoma, including natural killer (NK)-cell lymphoma. Although it mediates hydrolysis of asparagine (Asn) and glutamine (Gln), which are variably required for cancer cell survival, the relative contribution of Asn and Gln depletion to the anti-tumor activity in therapeutic doses...

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PMID: 26331698
DOI: 10.1111/cas.12807

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